Abstract
Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.
MeSH terms
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Aminoglycosides* / analysis
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Aminoglycosides* / chemistry
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Aminoglycosides* / pharmacology
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Aminoglycosides* / therapeutic use
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Methicillin-Resistant Staphylococcus aureus / cytology
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification*
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Mice
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Microbial Sensitivity Tests
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Molecular Probes* / analysis
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Molecular Probes* / chemistry
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Molecular Probes* / pharmacology
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Molecular Probes* / therapeutic use
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Molecular Structure
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Neomycin / analogs & derivatives
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Neomycin / chemistry
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Neomycin / pharmacology
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Neomycin / therapeutic use
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Particle Size
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RAW 264.7 Cells
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Staphylococcal Infections / diagnosis*
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / therapy*
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Molecular Probes
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Neomycin