Abstract
Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRPA) present a major problem for therapeutic management. We report here our experience with 12 patients with a severe MDRPA infection (6 of which were pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical treatment and/or suboptimal targeted treatment. Although 10 of the 12 patients (83.3%) experienced septic shock, only 3 patients (25%) died during the follow-up period. Microbiological cure in 7 patients (58.3%) was observed.
Keywords:
Pseudomonas aeruginosa; ceftolozane-tazobactam; salvage therapy.
Copyright © 2017 American Society for Microbiology.
MeSH terms
-
Adult
-
Aged
-
Anti-Bacterial Agents / therapeutic use*
-
Cephalosporins / therapeutic use*
-
Drug Resistance, Multiple, Bacterial*
-
Female
-
Humans
-
Male
-
Microbial Sensitivity Tests
-
Middle Aged
-
Penicillanic Acid / analogs & derivatives*
-
Penicillanic Acid / therapeutic use
-
Pneumonia, Bacterial / drug therapy*
-
Pneumonia, Bacterial / microbiology
-
Pneumonia, Bacterial / mortality
-
Pneumonia, Bacterial / pathology
-
Pseudomonas Infections / drug therapy*
-
Pseudomonas Infections / microbiology
-
Pseudomonas Infections / mortality
-
Pseudomonas Infections / pathology
-
Pseudomonas aeruginosa / drug effects
-
Pseudomonas aeruginosa / growth & development
-
Pseudomonas aeruginosa / pathogenicity*
-
Retrospective Studies
-
Salvage Therapy / methods
-
Shock, Septic / drug therapy*
-
Shock, Septic / microbiology
-
Shock, Septic / mortality
-
Shock, Septic / pathology
-
Survival Analysis
-
Tazobactam
Substances
-
Anti-Bacterial Agents
-
Cephalosporins
-
ceftolozane, tazobactam drug combination
-
Penicillanic Acid
-
Tazobactam