In Vivo Hyperthermic Stress Model: An Easy Tool to Study the Effects of Oxidative Stress on Neuronal Tau Functionality in Mouse Brain

Methods Mol Biol. 2017:1523:369-373. doi: 10.1007/978-1-4939-6598-4_25.

Abstract

Oxidative damage is an early event in neurodegenerative disorders such as Alzheimer disease. To increase oxidative stress in AD-related mouse models is essential to study early mechanisms involved in the physiopathology of these diseases. In this chapter, we describe an experimental mouse model of transient and acute hyperthermic stress to induce in vivo an increase of oxidative stress in the brain of any kind of wild-type or transgenic mouse.

Keywords: Brain; Heat stress; Hyperthermic stress; Neuron; Oxidative stress; Tau.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain / physiopathology*
  • Disease Models, Animal
  • Hyperthermia, Induced
  • Mice
  • Oxidation-Reduction
  • Oxidative Stress / genetics
  • Oxidative Stress / physiology*
  • tau Proteins / metabolism*

Substances

  • tau Proteins