Abstract
Integration is a key feature of the retroviral life cycle. This process involves packaging of the viral genome into chromatin, which is often assumed to occur as a post-integration step. In this issue of Cell Host & Microbe, Wang and colleagues (Wang et al., 2016) show that chromatinization occurs before integration, raising new questions about the role of histones in retroviral integration and transcription.
Copyright © 2016. Published by Elsevier Inc.
MeSH terms
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Acetylation
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Animals
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Capsid Proteins / metabolism
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Cell Line, Tumor
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Chromatin / genetics
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Chromatin / virology
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DNA, Viral / genetics
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DNA, Viral / physiology
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Embryonal Carcinoma Stem Cells / virology
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Epigenomics
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Fibroblasts
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Gene Expression Regulation, Viral
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Histones / metabolism
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Histones / physiology
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Humans
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Infections / metabolism
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Life Cycle Stages
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Mice
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Mouse Embryonic Stem Cells / virology
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Nucleocapsid Proteins / metabolism
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Retroviridae / genetics*
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Retroviridae / growth & development*
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Retroviridae Infections / therapy
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Retroviridae Infections / virology
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Transcription, Genetic
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Virus Assembly*
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Virus Integration / genetics*
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Virus Integration / physiology
Substances
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Capsid Proteins
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Chromatin
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DNA, Viral
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Histones
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Nucleocapsid Proteins