In patients with atypical Crohn's disease features, including severe oral ulcerations and resistance to standard treatment, the possibility of a mature clonal CD8+ T-cell lymphoproliferative disorder should be investigated. Clinicians should be aware of this differential diagnosis because CD8+ T-cell lymphoma prognosis can be remarkably favorable upon oral treatment with cyclophosphamide.
Keywords: Crohn's disease; cyclophosphamide; digestive lymphoma; peripheral T‐cell lymphoma.