siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
Nucleic Acids Res
.
2017 May 5;45(8):5008.
doi: 10.1093/nar/gkw1298.
Authors
Elad Elkayam
1
2
3
,
Rubina Parmar
4
,
Christopher R Brown
4
,
Jennifer L Willoughby
4
,
Christopher S Theile
4
,
Muthiah Manoharan
4
,
Leemor Joshua-Tor
1
2
3
Affiliations
1
Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.
2
Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.
3
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
4
Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
PMID:
27986853
PMCID:
PMC5416898
DOI:
10.1093/nar/gkw1298
No abstract available
Publication types
Published Erratum