Event-related potentials (ERPs) were used to investigate the effects of visual-spatial orienting on selective neural processing in boys with learning disabilities. Twenty-seven 8-12 year old boys were classified into four groups depending on whether or not they had a reading disability or attention deficit disorder. Event-related potentials were recorded over the left and right occipital, central, and frontal cortical regions. The behavioral task required the subjects 1) to rapidly switch their attention from the center to the periphery of the visual field (spatial component), and 2) to selectively respond to a target versus a nontarget flash when the target was presented in the relevant visual field (nonspatial component). The amplitude of two ERP components was enhanced in response to relevant as compared to irrelevant stimuli. The enhancement of an early negative occipital-central component, which peaked 180-200 ms following targets (N1), indicated that selective neural processing associated with spatial attention could be switched in 600 ms. This enhancement of N1 was greater in boys with than without a reading disability, which implies that reading disability is associated with enhanced spatial attention. The enhancement of a later positive component, which peaked 300-340 ms following targets (P3), suggested that nonspatial target selection was reduced in boys with a reading disability, particularly over the left occipital hemisphere. Target relevance and reading disability also influenced trial-to-trial variability in the ERP waveform. The effects of reading disability on event-related potentials did not vary as a function of attention deficit disorder, indicating that these two disorders are distinct.