Aberrant default mode network homogeneity in patients with first-episode treatment-naive melancholic depression

Xilong Cui; Wenbin Guo; Yi Wang; Tian-Xiao Yang; Xin-Hua Yang; Yefei Wang; Jingbo Gong; Changlian Tan; Guangrong Xie

doi:10.1016/j.ijpsycho.2016.12.005

Aberrant default mode network homogeneity in patients with first-episode treatment-naive melancholic depression

Int J Psychophysiol. 2017 Feb:112:46-51. doi: 10.1016/j.ijpsycho.2016.12.005. Epub 2016 Dec 15.

Authors

Xilong Cui¹, Wenbin Guo¹, Yi Wang², Tian-Xiao Yang², Xin-Hua Yang³, Yefei Wang⁴, Jingbo Gong⁴, Changlian Tan¹, Guangrong Xie⁵

Affiliations

¹ Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
² Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
³ Institute of Education, Hunan Agricultural University, Changsha, Hunan, China.
⁴ Department of Applied Psychology, Hunan University of Chinese Medicine, Changsha, Hunan, China.
⁵ Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address: [email protected].

PMID: 27989405
DOI: 10.1016/j.ijpsycho.2016.12.005

Abstract

Background: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD.

Methods: A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method.

Results: Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/TP). The abnormal NH of this region and clinical characteristics were not correlated.

Conclusion: Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder.

Keywords: Default mode network; Melancholic major depressive disorder; Network homogeneity; Resting-state imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Connectome*
Depressive Disorder, Major / physiopathology*
Female
Humans
Magnetic Resonance Imaging
Male
Temporal Lobe / physiopathology*
Young Adult