Cardiovascular profile in postural orthostatic tachycardia syndrome and Ehlers-Danlos syndrome type III

Clin Auton Res. 2017 Apr;27(2):113-116. doi: 10.1007/s10286-016-0392-4. Epub 2016 Dec 22.

Abstract

The cardiovascular profile of postural orthostatic tachycardia syndrome + Ehlers-Danlos syndrome hypermobility type (POTS + EDSIII) has not been described, despite suggestions that it plays a role in orthostatic intolerance. We studied nine individuals diagnosed with POTS + EDSIII and found that the arterial stiffness and cardiac profiles of patients with POTS + EDSIII were comparable to those of age- and sex-matched controls, suggesting an alternate explanation for orthostatic intolerance.

Keywords: Cardiovascular physiology; Echocardiography; Ehlers–Danlos syndrome type III; Postural orthostatic tachycardia syndrome; Vascular stiffness.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiovascular Physiological Phenomena*
  • Ehlers-Danlos Syndrome / diagnosis
  • Ehlers-Danlos Syndrome / physiopathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Postural Orthostatic Tachycardia Syndrome / diagnosis
  • Postural Orthostatic Tachycardia Syndrome / physiopathology*
  • Vascular Stiffness / physiology*
  • Vasoconstriction / physiology
  • Young Adult

Supplementary concepts

  • Ehlers-Danlos syndrome type 3