Recent advances on the encoding and selection methods of DNA-encoded chemical library

Bingbing Shi; Yu Zhou; Yiran Huang; Jianfu Zhang; Xiaoyu Li

doi:10.1016/j.bmcl.2016.12.025

Recent advances on the encoding and selection methods of DNA-encoded chemical library

Bioorg Med Chem Lett. 2017 Feb 1;27(3):361-369. doi: 10.1016/j.bmcl.2016.12.025. Epub 2016 Dec 9.

Authors

Bingbing Shi¹, Yu Zhou¹, Yiran Huang², Jianfu Zhang², Xiaoyu Li³

Affiliations

¹ Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
² Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
³ Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region. Electronic address: [email protected].

PMID: 28011218
DOI: 10.1016/j.bmcl.2016.12.025

Abstract

DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.

Keywords: Combinatorial chemistry; DNA-encoded library; Drug discovery; Dynamic combinatorial library; High throughput screening.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques
DNA / chemistry
DNA / metabolism*
Drug Discovery
High-Throughput Screening Assays
Ligands
Nucleic Acid Hybridization
Small Molecule Libraries / chemistry
Small Molecule Libraries / metabolism*

Substances

Ligands
Small Molecule Libraries
DNA