Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells

Christian Meinert; Franziska Kohse; Ilka Böhme; Florian Gembardt; Anja Tetzner; Thomas Wieland; Barry Greenberg; Thomas Walther

doi:10.1016/j.dib.2016.12.004

Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells

Data Brief. 2016 Dec 8:10:354-363. doi: 10.1016/j.dib.2016.12.004. eCollection 2017 Feb.

Authors

Christian Meinert¹, Franziska Kohse², Ilka Böhme², Florian Gembardt³, Anja Tetzner⁴, Thomas Wieland⁵, Barry Greenberg⁶, Thomas Walther⁷

Affiliations

¹ Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
² Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
³ Division of Nephrology, Department of Internal Medicine III, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
⁴ Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
⁵ Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany.
⁶ Division of Cardiology, University of California, San Diego, USA.
⁷ Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.

Abstract

In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1-7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1-7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1-7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.

Keywords: Angiotensin-(1-7); Antibody microarray; Cell signaling; Endothelium; Renin-Angiotensin system.

Grants and funding

R01 HL091191/HL/NHLBI NIH HHS/United States