Copy number alterations unmasked as enhancer hijackers

Nat Genet. 2016 Dec 28;49(1):5-6. doi: 10.1038/ng.3754.

Abstract

Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.

Publication types

  • Comment

MeSH terms

  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 8
  • DNA Copy Number Variations*
  • Enhancer Elements, Genetic*
  • GATA2 Transcription Factor / genetics
  • GATA2 Transcription Factor / metabolism
  • Gene Dosage
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Insulin-Like Growth Factor II / genetics
  • Insulin-Like Growth Factor II / metabolism
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism
  • T-Cell Acute Lymphocytic Leukemia Protein 1

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • GATA2 Transcription Factor
  • GATA2 protein, human
  • IGF2 protein, human
  • MYC protein, human
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myc
  • T-Cell Acute Lymphocytic Leukemia Protein 1
  • TAL1 protein, human
  • Insulin-Like Growth Factor II