Radical Cation Cycloadditions Using Cleavable Redox Auxiliaries

Org Lett. 2017 Jan 20;19(2):368-371. doi: 10.1021/acs.orglett.6b03545. Epub 2016 Dec 29.

Abstract

The incorporation of an easily oxidized arylsulfide moiety facilitates the photocatalytic generation of alkene radical cations that undergo a variety of cycloaddition reactions with electron-rich reaction partners. The sulfide moiety can subsequently be reductively cleaved in a traceless fashion, affording products that are not otherwise directly accessible using photoredox catalysis. This approach constitutes a novel oxidative "redox auxiliary" strategy that offers a practical means to circumvent a fundamental thermodynamic limitation facing photoredox reactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cations / chemistry*
  • Cycloaddition Reaction
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Cations