Comparison of lung damage in mice exposed to black carbon particles and 1,4-naphthoquinone coated black carbon particles

Hongqian Chu; Jing Shang; Ming Jin; Yueyue Chen; Yao Pan; Yuan Li; Xi Tao; Zhiyuan Cheng; Qinghe Meng; Qian Li; Guang Jia; Tong Zhu; Weidong Hao; Xuetao Wei

doi:10.1016/j.scitotenv.2016.11.214

Comparison of lung damage in mice exposed to black carbon particles and 1,4-naphthoquinone coated black carbon particles

Sci Total Environ. 2017 Feb 15:580:572-581. doi: 10.1016/j.scitotenv.2016.11.214. Epub 2016 Dec 27.

Authors

Hongqian Chu¹, Jing Shang², Ming Jin¹, Yueyue Chen², Yao Pan¹, Yuan Li¹, Xi Tao¹, Zhiyuan Cheng¹, Qinghe Meng¹, Qian Li³, Guang Jia⁴, Tong Zhu², Weidong Hao⁵, Xuetao Wei⁶

Affiliations

¹ Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
² State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China.
³ State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, PR China; POTEN Environment Group Co., Ltd., Beijing 100082, PR China.
⁴ Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
⁵ Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China. Electronic address: [email protected].
⁶ Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China. Electronic address: [email protected].

PMID: 28034545
DOI: 10.1016/j.scitotenv.2016.11.214

Abstract

Black carbon (BC) is a key component of atmospheric particles and has a significant effect on human health. BC can provide reactive sites and surfaces thus absorb quinones which were primarily generated from fossil fuel combustion and/or atmospheric photochemical conversions of PAHs. Oxidation could change the characteristics of BC and increase its toxicity. The comparison of lung damage in mice exposed to BC and 1,4-NQ-coated BC (1,4NQ-BC) particles is investigated in this study. Mice which were intratracheally instilled with particles have a higher expression of IL-1β, IL-6 and IL-33 in bronchoalveolar lavage fluid (BALF). Also, the IL-6, IL-33 mRNA expression in the lung tissue of mice instilled with 1,4NQ-BC were higher than that of mice instilled with BC. The pathology results showed that the lung tissue of mice instilled with 1,4NQ-BC particles have much more inflammatory cells infiltration than that of mice treated with BC. It is believed that the MAPK and PI3K-AKT pathway might be involved in the 1,4NQ-BC particles caused lung damage. Results indicated that 1,4NQ-BC particles in the atmosphere may cause more damage to health.

Keywords: 1,4NQ-BC; Black carbon; IL-33; Lung.

Publication types

Comparative Study

MeSH terms

Air Pollutants / adverse effects*
Animals
Bronchoalveolar Lavage Fluid
Carbon / adverse effects*
Inflammation
Interleukins / analysis
Lung / drug effects
Lung / pathology*
Mice
Naphthoquinones / adverse effects*
Phosphatidylinositol 3-Kinases
Soot / adverse effects*

Substances

Air Pollutants
Interleukins
Naphthoquinones
Soot
Carbon
Phosphatidylinositol 3-Kinases
1,4-naphthoquinone