Abstract
Cicletanine, a new furopyridine derivative synthetized by the Institut Henri Beaufour (France) was found to work as an efficient antihypertensive agent in DOCA-salt rats. This compound also inhibited the development of cardiac hypertrophy characteristic of this sort of hypertension. The mechanism of antihypertensive action at nondiuretic doses of cicletanine remains to be studied.
MeSH terms
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Animals
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Anti-Arrhythmia Agents / administration & dosage
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Anti-Arrhythmia Agents / therapeutic use*
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Blood Pressure / drug effects
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Desoxycorticosterone
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Diuretics / administration & dosage
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Diuretics / therapeutic use*
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Dose-Response Relationship, Drug
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Heart Rate / drug effects
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Hypertension / chemically induced
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Hypertension / drug therapy*
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Hypertension / physiopathology
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Male
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Pyridines*
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Rats
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Rats, Inbred Strains
Substances
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Anti-Arrhythmia Agents
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Diuretics
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Pyridines
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Desoxycorticosterone
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cicletanine