Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography

Appl Radiat Isot. 2017 Mar:121:76-81. doi: 10.1016/j.apradiso.2016.11.020. Epub 2016 Dec 2.

Abstract

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [11C]CO2 conversion into the highly reactive methylating agents [11C]CH3I and [11C]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[11C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

Keywords: Automated radiolabeling; Carbon-11 radiotracers; Kit-like production; Positron Emission Tomography.

MeSH terms

  • Automation / instrumentation
  • Automation / methods
  • Carbon Radioisotopes / chemistry
  • Carbon Radioisotopes / isolation & purification*
  • Equipment Design
  • Equipment Reuse
  • Humans
  • Isotope Labeling / instrumentation
  • Isotope Labeling / methods*
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / isolation & purification*

Substances

  • Carbon Radioisotopes
  • Carbon-11
  • Radiopharmaceuticals