The incredible complexity of RNA splicing

Genome Biol. 2016 Dec 30;17(1):265. doi: 10.1186/s13059-016-1121-y.

Abstract

Alternative splice isoforms are common and important and have been shown to impact many human diseases. A new study by Nellore et al. offers a comprehensive study of splice junctions in humans by re-analyzing over 21,500 public human RNA sequencing datasets.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alternative Splicing
  • Animals
  • Genetic Predisposition to Disease
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Molecular Sequence Annotation
  • RNA Splice Sites
  • RNA Splicing / genetics*

Substances

  • RNA Splice Sites