Pla a 2 and Pla a 3 reactivities identify plane tree-allergic patients with respiratory symptoms or food allergy

Allergy. 2017 Apr;72(4):671-674. doi: 10.1111/all.13121. Epub 2017 Jan 19.

Abstract

Nine hundred and thirty-nine rPla a 1, nPla a 2, and rPla a 3 ImmunoCAP ISAC reactors were studied. nPla a 2pos MUXF3pos but Pla a 1/2neg subjects were excluded from the study because they were cross-reactive carbohydrate determinant reactors. Among the 764 remaining participants, 71.9% were Pla a 3pos , 54.1% Pla a 2pos , and 10.9% Pla a 1pos . Among Pla a 3 reactors, 89.6% were Pru p 3pos and 86.8% Jug 3pos , but the strongest IgE recognition relationship was observed between Pla a 3 and Jug r 3. Distinctive clinical subsets could be documented among plane tree-allergic patients. Pla a 3 reactors had both local and systemic food-induced reactions, but lower past respiratory symptoms occurrence. Pla a 2 reactivity was associated with respiratory symptoms but inversely related to systemic reactions to food. Cosensitization to Pla a 2 and Pla a 3 was associated with a lower past incidence of severe food-induced reactions.

Keywords: Jug r 3; Pla a 2; Pla a 3; nonspecific lipid transfer protein; plane tree.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Allergens / immunology*
  • Antigens, Plant / immunology*
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Food Hypersensitivity / diagnosis*
  • Humans
  • Hypersensitivity / diagnosis*
  • Hypersensitivity / immunology*
  • Immunoglobulin E / immunology
  • Infant
  • Male
  • Middle Aged
  • Odds Ratio
  • Symptom Assessment
  • Tracheophyta / adverse effects*
  • Trees*
  • Young Adult

Substances

  • Allergens
  • Antigens, Plant
  • Pla a 2, Platanus acerifolia
  • Immunoglobulin E