Identification and characterization a novel HLA-A allele, A*02:355, by sequence-based typing in a Chinese potential donor

X-M Nie; Y Zhang; W-B Qiao; C-F Zhu; Y-R Zhao

doi:10.1111/iji.12302

Identification and characterization a novel HLA-A allele, A*02:355, by sequence-based typing in a Chinese potential donor

Int J Immunogenet. 2017 Feb;44(1):35-37. doi: 10.1111/iji.12302. Epub 2017 Jan 2.

Authors

X-M Nie^{1

2}, Y Zhang², W-B Qiao², C-F Zhu², Y-R Zhao¹

Affiliations

¹ Department of Central Laboratory, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
² HLA Laboratory, Blood Center of Shandong Province, Jinan, China.

PMID: 28044416
DOI: 10.1111/iji.12302

Abstract

The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.

MeSH terms

Alleles*
Amino Acid Substitution*
Asian People
Base Sequence
Exons
Gene Expression
HLA-A2 Antigen / genetics*
HLA-A2 Antigen / immunology
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Mutation*
Sequence Analysis, DNA
Tissue Donors

Substances

HLA-A*02 antigen
HLA-A2 Antigen