Adults with initial metabolic syndrome have altered muscle deoxygenation during incremental exercise

Objective: Reduced aerobic power is independently associated with metabolic syndrome (MetS) incidence and prevalence in adults. This study investigated whether muscle deoxygenation (proxy of microvascular O₂ extraction) during incremental exercise is altered in MetS and associated with reduced oxygen consumption ( V˙O_2peak ).

Methods: Twelve men with initial MetS (no overt diseases and medication-naive; mean ± SD, age 38 ± 7 years) and 12 healthy controls (HCs) (34 ± 7 years) completed an incremental cycling test to exhaustion, in which pulmonary ventilation and gas exchange (metabolic analyzer), as well as vastus lateralis deoxygenation (near infrared spectroscopy), were measured.

Results: Subjects with MetS, in contrast to HCs, showed lower V˙O_2peak normalized to total lean mass, similar V˙O₂ response to exercise, and earlier break point (BP) in muscle deoxygenation. Consequently, deoxygenation slope from BP to peak exercise was greater. Furthermore, absolute V˙O_2peak was positively associated with BP in correlations adjusted for total lean mass.

Conclusions: MetS, without overt diseases, altered kinetics of muscle deoxygenation during incremental exercise, particularly at high-intensity exercise. Therefore, the balance between utilization and delivery of O₂ within skeletal muscle is impaired early in MetS natural history, which may contribute to the reduction in aerobic power.