Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study

J Diabetes. 2017 Nov;9(11):1040-1047. doi: 10.1111/1753-0407.12523. Epub 2017 Feb 27.

Abstract

Background: Increasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome.

Methods: A cross-sectional study was conducted on 3641 participants aged ≥40 years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome.

Results: Multivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P trend = 0.005). In addition, participants with elevated serum CA 19-9 (≥37 U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9 < 37 U/mL (multivariate adjusted OR 2.10; 95% CI 1.21-3.65).

Conclusion: Serum CA 19-9 is associated with an increased risk of prevalent metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed.

Keywords: CA 19-9; association; metabolic syndrome; 代谢综合征; 相关性.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian People
  • Biomarkers / blood*
  • CA-19-9 Antigen / blood*
  • China
  • Cross-Sectional Studies
  • Female
  • Humans
  • Logistic Models
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / diagnosis*
  • Metabolic Syndrome / ethnology
  • Middle Aged
  • Multivariate Analysis

Substances

  • Biomarkers
  • CA-19-9 Antigen