High Incidence of Escherichia coli Strains Coharboring mcr-1 and blaNDM from Chickens

Bao-Tao Liu; Feng-Jing Song; Ming Zou; Qi-Di Zhang; Hu Shan

doi:10.1128/AAC.02347-16

High Incidence of Escherichia coli Strains Coharboring mcr-1 and bla_NDM from Chickens

Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02347-16. doi: 10.1128/AAC.02347-16. Print 2017 Mar.

Authors

Bao-Tao Liu^{1

2}, Feng-Jing Song³, Ming Zou⁴, Qi-Di Zhang⁴, Hu Shan^{4

2}

Affiliations

¹ College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China [email protected].
² Engineering Technology Research Center of Veterinary Medicine and Diagnostic Reagents of Shandong Province, Qingdao Agricultural University, Qingdao, China.
³ Qingdao Academy of Agricultural Sciences, Qingdao, China.
⁴ College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.

Abstract

This study investigated the characteristics of Escherichia coli isolates carrying mcr-1-bla_NDM from a chicken farm in China. Of the 78 E. coli isolates, 21 clonally unrelated isolates carried mcr-1-bla_NDM Diverse IncI2 plasmids disseminated mcr-1, while the dissemination of bla_NDM was mediated by diverse IncB/O plasmids. More striking was the colocalization of resistance genes mcr-1 and bla_NDM-4 in an IncHI2/ST3 plasmid, which might pose a great challenge for public health.

Keywords: Escherichia coli; blaNDM; colocalization; high incidence; mcr-1.

MeSH terms

Animal Husbandry
Animals
Anti-Bacterial Agents / pharmacology
Carbapenems / pharmacology
Chickens
China / epidemiology
Clone Cells
Colistin / pharmacology
Drug Resistance, Multiple, Bacterial / genetics*
Escherichia coli / drug effects
Escherichia coli / genetics
Escherichia coli / growth & development
Escherichia coli Infections / drug therapy
Escherichia coli Infections / epidemiology
Escherichia coli Infections / transmission
Escherichia coli Infections / veterinary*
Escherichia coli Proteins / genetics*
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial*
Gene Transfer, Horizontal
Microbial Sensitivity Tests
Plasmids / chemistry
Plasmids / metabolism*
Poultry Diseases / drug therapy
Poultry Diseases / epidemiology*
Poultry Diseases / microbiology
Poultry Diseases / transmission
beta-Lactamases / genetics*
beta-Lactamases / metabolism

Substances

Anti-Bacterial Agents
Carbapenems
Escherichia coli Proteins
MCR-1 protein, E coli
beta-Lactamases
beta-lactamase NDM-1
Colistin