Hepatitis E Virus (HEV) Infection in Anti-HEV Immunoglobulin G-Carrying Patients After Successful Hepatitis C Virus Treatment: Reactivation or Reinfection?

Clin Infect Dis. 2017 Apr 1;64(7):964-966. doi: 10.1093/cid/cix004.

Abstract

Although hepatitis E virus (HEV) is regarded as a self-limiting infection and anti-HEV antibodies seem to protect against reinfection, its pathogenesis is not well established. We describe 2 cases of acute symptomatic HEV infection after hepatitis C therapy in patients carrying anti-HEV immunoglobulin G antibodies, raising 2 major questions: reactivation or reinfection?

Keywords: HIV; hepatitis C; hepatitis E; reactivation.; reinfection.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiretroviral Therapy, Highly Active
  • Antiviral Agents / therapeutic use
  • Coinfection
  • Female
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy
  • HIV Infections / virology
  • Hepatitis Antibodies / blood
  • Hepatitis Antibodies / immunology*
  • Hepatitis C / drug therapy
  • Hepatitis C / virology
  • Hepatitis E / diagnosis
  • Hepatitis E / immunology*
  • Hepatitis E / virology*
  • Hepatitis E virus / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology*
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology
  • Male
  • Middle Aged
  • Viral Load
  • Virus Activation

Substances

  • Antiviral Agents
  • Hepatitis Antibodies
  • Immunoglobulin G
  • Immunoglobulin M