Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines

Subrata Chakraborty; Gregory Leitus; David Milstein

doi:10.1002/anie.201608537

Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2074-2078. doi: 10.1002/anie.201608537. Epub 2017 Jan 12.

Authors

Subrata Chakraborty¹, Gregory Leitus¹, David Milstein¹

Affiliation

¹ Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel.

PMID: 28078777
DOI: 10.1002/anie.201608537

Abstract

The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.

Keywords: cross-coupling; hydrogenation; imines; iron; nitriles.

Publication types

Research Support, Non-U.S. Gov't