Two cases of serious rhabdomyolysis during linezolid treatment

Infection. 2017 Aug;45(4):563-566. doi: 10.1007/s15010-016-0978-8. Epub 2017 Jan 12.

Abstract

Linezolid is an oxazolidinone antibiotic with activity against gram-positive organisms, particularly methicillin-resistant Staphylococcus aureus (MRSA). To the best of our knowledge, there are only two case reports on rhabdomyolysis in patients treated with linezolid. Here, we describe two cases of serious rhabdomyolysis: one in a patient with septic community-acquired (CA)-MRSA pneumonia and a second case in a patient with suspected catheter-related blood stream infection.

Keywords: Linezolid; MRSA pneumonia; MRSA sepsis; Rhabdomyolysis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / toxicity*
  • Austria
  • Diagnosis, Differential
  • Female
  • Humans
  • India
  • Linezolid / toxicity*
  • Male
  • Methicillin-Resistant Staphylococcus aureus / physiology
  • Middle Aged
  • Rhabdomyolysis / chemically induced
  • Rhabdomyolysis / diagnosis*
  • Rhabdomyolysis / drug therapy*
  • Staphylococcal Infections / drug therapy*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Linezolid