Distant spread of a supratentorial glioblastoma to the spinal cord

Krishnan Ravindran; Frank Gaillard; Arian Lasocki

doi:10.1016/j.jocn.2016.11.010

Distant spread of a supratentorial glioblastoma to the spinal cord

J Clin Neurosci. 2017 Apr:38:56-57. doi: 10.1016/j.jocn.2016.11.010. Epub 2017 Jan 12.

Authors

Krishnan Ravindran¹, Frank Gaillard², Arian Lasocki³

Affiliations

¹ Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia.
² Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Radiology, The University of Melbourne, Parkville, VIC, Australia.
³ Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Monash Imaging, Monash Health, Clayton, VIC, Australia. Electronic address: [email protected].

PMID: 28089418
DOI: 10.1016/j.jocn.2016.11.010

Abstract

Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour.

Keywords: Extra-cranial; Glioblastoma; Metastasis; Spinal.

Publication types

Case Reports

MeSH terms

Glioblastoma / diagnosis*
Glioblastoma / pathology
Humans
Male
Middle Aged
Spinal Cord Neoplasms / diagnosis*
Spinal Cord Neoplasms / pathology
Spinal Cord Neoplasms / secondary
Supratentorial Neoplasms / diagnosis*
Supratentorial Neoplasms / pathology