Reduced effects of age on dopamine D2 receptor levels in physically active adults

Linh C Dang; Jaime J Castrellon; Scott F Perkins; Nam T Le; Ronald L Cowan; David H Zald; Gregory R Samanez-Larkin

doi:10.1016/j.neuroimage.2017.01.018

Reduced effects of age on dopamine D2 receptor levels in physically active adults

Neuroimage. 2017 Mar 1:148:123-129. doi: 10.1016/j.neuroimage.2017.01.018. Epub 2017 Jan 10.

Authors

Linh C Dang¹, Jaime J Castrellon², Scott F Perkins², Nam T Le³, Ronald L Cowan⁴, David H Zald⁵, Gregory R Samanez-Larkin⁶

Affiliations

¹ Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA. Electronic address: [email protected].
² Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA.
³ Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA.
⁴ Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Ave South, Nashville, TN 37212, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA.
⁵ Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA; Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Ave South, Nashville, TN 37212, USA.
⁶ Department of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, CT 06520, USA. Electronic address: [email protected].

Abstract

Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.

Keywords: Aging; Dopamine; Physical activity.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Aged
Aged, 80 and over
Aging / metabolism*
Benzamides
Brain / diagnostic imaging
Brain / growth & development
Brain / physiology
Cross-Sectional Studies
Exercise / physiology*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography
Radiopharmaceuticals
Receptors, Dopamine D2 / metabolism
Receptors, Dopamine D2 / physiology*
Receptors, Dopamine D3 / metabolism
Young Adult

Substances

Benzamides
DRD2 protein, human
Radiopharmaceuticals
Receptors, Dopamine D2
Receptors, Dopamine D3
fallypride

Abstract

Publication types

MeSH terms

Substances

Grants and funding