Abstract
We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.
MeSH terms
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Aging / metabolism*
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Animals
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Apoptosis / physiology
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Cell Death
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Forkhead Box Protein O1 / metabolism
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Humans
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Mitochondria, Muscle / metabolism*
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Mitophagy
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Motor Neurons / metabolism
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Muscle, Skeletal / innervation
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Muscle, Skeletal / metabolism*
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Muscular Atrophy / metabolism
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Sarcopenia / metabolism*
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Signal Transduction
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Ubiquitin / metabolism
Substances
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Forkhead Box Protein O1
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Ubiquitin