P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

Transcription. 2018;9(2):88-94. doi: 10.1080/21541264.2017.1281864. Epub 2018 Jan 12.

Abstract

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

Keywords: 7SK snRNP; Brd4; KAP1; P-TEFb; RNA Pol II; SEC; promoter-proximal pausing; transcription elongation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Humans
  • Positive Transcriptional Elongation Factor B / metabolism*
  • Promoter Regions, Genetic*
  • RNA Polymerase II / metabolism*
  • Signal Transduction

Substances

  • Positive Transcriptional Elongation Factor B
  • RNA Polymerase II