Treatment of the axilla in patients with primary breast cancer and low burden axillary disease: Limitations of the evidence from randomised controlled trials

Crit Rev Oncol Hematol. 2017 Feb:110:74-80. doi: 10.1016/j.critrevonc.2016.11.011. Epub 2016 Nov 25.

Abstract

Invasive breast cancer is the second most common cancer worldwide. It is known to metastasise to the regional axillary lymph nodes but there has been debate over what is the best way to stage and treat the axilla in patients presenting with primary breast cancer. Multiple trials over the last two decades have led to a change in practice from routine axillary lymph node dissection to sentinel lymph node biopsy in patients who are clinically lymph node negative preoperatively. This has resulted in new questions regarding subsequent treatment of some patients. This review will critically appraise the evidence on axillary treatment in patients with low burden axillary disease and highlight limitations of relevant randomised controlled trials.

Keywords: Axilla; Breast cancer; Surgery.

Publication types

  • Review

MeSH terms

  • Axilla
  • Breast Neoplasms / complications
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery*
  • Humans
  • Lymph Node Excision / methods
  • Lymph Nodes / pathology
  • Lymph Nodes / surgery*
  • Lymphatic Metastasis
  • Randomized Controlled Trials as Topic
  • Sentinel Lymph Node Biopsy