Choline-based imaging of prostate cancer with combined [18F] fluorocholine PET and 1H MR spectroscopy by means of integrated PET/MRI

Clin Imaging. 2017 Mar-Apr:42:198-202. doi: 10.1016/j.clinimag.2016.12.008. Epub 2017 Jan 7.

Abstract

Purpose: To evaluate integrated PET/MRI/1H MR spectroscopy in patients with prostate cancer.

Subjects and methods: Data analysis comprised calculations of correlations of standardized uptake values (SUVs) and ratios of (choline+creatine)/citrate as well as of single metabolite values and a logistic regression analysis of PET data and MR spectroscopy data in 22 patients.

Results: SUVmean and integral values of choline correlated significantly in tumors. Logistic regression analysis demonstrated diagnostic superiority of PET over spectroscopy.

Conclusion: Simultaneous acquisition of PET and MR spectroscopy with integrated PET/MRI is feasible. Choline compounds and choline metabolism show a positive significant correlation.

Keywords: MR spectroscopy; Molecular imaging; PET/MRI; Prostate cancer; [(18)F] choline.

MeSH terms

  • Aged
  • Choline / analogs & derivatives
  • Creatine
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Positron-Emission Tomography / methods*
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / pathology

Substances

  • fluorocholine
  • Creatine
  • Choline