Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin

J Allergy Clin Immunol. 2017 Jun;139(6):2023-2026.e9. doi: 10.1016/j.jaci.2016.12.954. Epub 2017 Jan 19.

Authors

Jie Chen¹, Jihui Zhang¹, Theresa Tachie-Menson¹, Neha Shukla¹, David R Garrod², Clive Robinson³

Affiliations

¹ Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.
² Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
³ Institute for Infection and Immunity, St George's, University of London, London, United Kingdom. Electronic address: [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ADAM10 Protein / metabolism*
Allergens / immunology*
Enzyme Activation
Humans
Intracellular Space
Oxidants / metabolism*
Prothrombin / metabolism*
Reactive Oxygen Species
Receptors, Purinergic / metabolism*
Recombinant Proteins

Substances

Allergens
Oxidants
Reactive Oxygen Species
Receptors, Purinergic
Recombinant Proteins
Prothrombin
ADAM10 Protein

Grants and funding