Utility of neurological smears for intrasurgical brain cancer diagnostics and tumour cell percentage by DESI-MS

V Pirro; A K Jarmusch; C M Alfaro; E M Hattab; A A Cohen-Gadol; R Graham Cooks

doi:10.1039/c6an02645a

Utility of neurological smears for intrasurgical brain cancer diagnostics and tumour cell percentage by DESI-MS

Analyst. 2017 Jan 26;142(3):449-454. doi: 10.1039/c6an02645a.

Authors

V Pirro¹, A K Jarmusch¹, C M Alfaro¹, E M Hattab², A A Cohen-Gadol³, R Graham Cooks¹

Affiliations

¹ Department of Chemistry, Purdue University, West Lafayette, IN, USA. [email protected].
² Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA. [email protected].
³ Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. [email protected].

PMID: 28112301
DOI: 10.1039/c6an02645a

Abstract

Analysis of neurological smears by desorption electrospray ionization mass spectrometry (DESI-MS) is an emerging diagnostic strategy for intraoperative consultation in brain tumor resection. DESI-MS allows rapid sampling while providing accurate diagnostic information. We assess the chemical homogeneity of neurological smears using DESI-MS imaging and the quality of rapid DESI-MS diagnosis.

MeSH terms

Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / surgery*
Humans
Spectrometry, Mass, Electrospray Ionization*