In a special issue of the Lancet, an update of the Global Burden of Disease project has been presented, covering the period 1980-2015, with results from 195 countries in the world. 1800 experts from all over the world have helped in collecting and reviewing data. Mortality, disability, contribution of risk factors, and fulfilment of the Sustainable Goals have been analyzed. With data now available on the web the results give valuable information for analysis and policy development in countries and regions.