Modelling the occurrence and pathology of Alzheimer's disease

Neurobiol Aging. 1989 Sep-Oct;10(5):429-31; discussion 446-8. doi: 10.1016/0197-4580(89)90084-5.

Abstract

Our work has confirmed that of St. George-Hyslop and colleagues, suggesting FAD linkage to the short arm of chromosome 21 in outbred families with a presenile onset of the disease. Future genetic studies should help clarify the current apparent discrepancies between certain laboratories and ultimately lead to a better understanding of the variables which predispose individuals to the disease.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology
  • Chromosomes, Human, Pair 21*
  • Genetic Linkage*
  • Humans
  • Middle Aged