Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder

Expert Opin Ther Targets. 2017 Mar;21(3):235-237. doi: 10.1080/14728222.2017.1287899.
No abstract available

Keywords: HCN; Pex5; TRIP8b; depression; ion channel.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology*
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / physiopathology
  • Disease Models, Animal
  • Humans
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism*
  • Receptors, Cytoplasmic and Nuclear / metabolism*

Substances

  • Antidepressive Agents
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • PEX5L protein, human
  • Receptors, Cytoplasmic and Nuclear