IFN-β induces greater antiproliferative and proapoptotic effects and increased p53 signaling compared with IFN-α in PBMCs of Adult T-cell Leukemia/Lymphoma patients

Blood Cancer J. 2017 Jan 27;7(1):e519. doi: 10.1038/bcj.2016.126.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Proliferation / drug effects
  • Female
  • Humans
  • Interferon-alpha / pharmacology*
  • Interferon-beta / pharmacology*
  • Leukemia-Lymphoma, Adult T-Cell / pathology*
  • Leukocytes, Mononuclear / drug effects*
  • Male
  • Middle Aged
  • Signal Transduction / drug effects
  • Tumor Cells, Cultured
  • Tumor Suppressor Protein p53 / drug effects
  • Tumor Suppressor Protein p53 / metabolism
  • Young Adult

Substances

  • Antineoplastic Agents
  • Interferon-alpha
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Interferon-beta