Abstract
A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém's offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL).
Keywords:
Aspergillus niger; Marine-derived fungi; cytotoxic activity; furan derivative.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Aspergillus niger / chemistry*
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Brazil
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Cyclohexanones / isolation & purification
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Cyclohexanones / pharmacology
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Dipeptides / isolation & purification
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Dipeptides / pharmacology
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Drug Screening Assays, Antitumor
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Epoxy Compounds / isolation & purification
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Epoxy Compounds / pharmacology
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Furans / chemistry
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Geologic Sediments / microbiology
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HCT116 Cells
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology
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Pyrrolidinones / isolation & purification
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Pyrrolidinones / pharmacology
Substances
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Antineoplastic Agents
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Cyclohexanones
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Dipeptides
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Epoxy Compounds
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Furans
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Peptides, Cyclic
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Pyrrolidinones
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chlovalicin
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cyclo(prolyl-leucyl)
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pseurotin
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malformin C