Molecular imaging of mucosal α4β7 integrin expression with the fluorescent anti-adhesion antibody vedolizumab in Crohn's disease

Gastrointest Endosc. 2017 Aug;86(2):406-408. doi: 10.1016/j.gie.2017.01.012. Epub 2017 Jan 27.

Authors

Timo Rath¹, Christian Bojarski², Markus F Neurath¹, Raja Atreya¹

Affiliations

¹ Department of Medicine 1, Friedrich-Alexander University Erlangen-Nuernberg, Division of Gastroenterology, Endocrinology and Pneumology, Ludwig Demling Endoscopy Center of Excellence, Erlangen, Germany.
² Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Gastroenterology, Berlin, Germany.

PMID: 28137597
DOI: 10.1016/j.gie.2017.01.012

No abstract available

MeSH terms

Antibodies, Monoclonal, Humanized / therapeutic use*
Crohn Disease / drug therapy*
Crohn Disease / metabolism*
Endoscopy, Gastrointestinal
Fluorescein-5-isothiocyanate
Fluorescent Antibody Technique
Fluorescent Dyes
Gastrointestinal Agents / therapeutic use*
Humans
Integrins / metabolism*
Intestinal Mucosa / metabolism
Microscopy, Confocal
Molecular Imaging*

Substances

Antibodies, Monoclonal, Humanized
Fluorescent Dyes
Gastrointestinal Agents
Integrins
integrin alpha4beta7
vedolizumab
Fluorescein-5-isothiocyanate