Building the Class 2 CRISPR-Cas Arsenal

Kevin M Lewis; Ailong Ke

doi:10.1016/j.molcel.2017.01.024

Building the Class 2 CRISPR-Cas Arsenal

Mol Cell. 2017 Feb 2;65(3):377-379. doi: 10.1016/j.molcel.2017.01.024.

Authors

Kevin M Lewis¹, Ailong Ke²

Affiliations

¹ Department of Molecular Biology and Genetics, Cornell University, 251 Biotechnology Building, Ithaca, NY 14853, USA.
² Department of Molecular Biology and Genetics, Cornell University, 251 Biotechnology Building, Ithaca, NY 14853, USA. Electronic address: [email protected].

PMID: 28157502
DOI: 10.1016/j.molcel.2017.01.024

Abstract

Adaptation of CRISPR-Cas9 for genome-editing applications has revolutionized biomedical research. New single-component effector CRISPR systems are emerging from the bioinformatics pipeline. How can we best harness their power? Three new studies will no doubt facilitate this transition by generating the C2c1 and C2c2 structure snapshots in different functional states.

Keywords: C2c1; C2c2; C2c3; CRISPR; Cas; Cas9; Cpf1; immunity; interference; type II.

MeSH terms

CRISPR-Associated Proteins / chemistry
CRISPR-Cas Systems*
Gene Editing / methods*
Genetic Engineering / methods
Models, Molecular

Substances

CRISPR-Associated Proteins