Abstract
We present a rare case of grade II lymphomatoid granulomatosis (LYG) with pulmonary and gastrointestinal involvement. LYG is considered an Epstein-Barr virus-driven lymphoproliferative disorder that often presents with multiple nodular lesions in the lungs and sometimes involvement of skin and the central nervous system. Although the aetiology is unknown, it is associated with the use of immunosuppressives. Involvement of other organ systems is very rare. We successfully treated our patients with 6 cycles of R-CHOP and autologous stem cell transplantation with a major response at 20 months follow-up.
2017 BMJ Publishing Group Ltd.
MeSH terms
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Aged
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Antineoplastic Agents / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Female
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Fever / etiology
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Hematemesis / etiology
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Hematopoietic Stem Cell Transplantation / methods
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Herpesvirus 4, Human
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Humans
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / pathology*
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Lymphomatoid Granulomatosis / diagnosis*
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Lymphomatoid Granulomatosis / drug therapy
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Lymphomatoid Granulomatosis / pathology
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Prednisone / therapeutic use
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Rituximab / therapeutic use
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Stomach Neoplasms / diagnosis*
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Stomach Neoplasms / drug therapy
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Vincristine / therapeutic use
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Weight Loss
Substances
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Antineoplastic Agents
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone