Keywords: APD, acquired perforating dermatosis; CRF, chronic renal failure; DM, diabetes mellitus; EPS, elastosis perforans serpiginosa; ESRD, end-stage renal disease; RPC, reactive perforating collagenosis; acquired perforating dermatosis; elastosis perforans serpiginosa; end-stage renal disease; generalized eruption; giant variant; perforating dermatosis.