Regional cerebral blood flow assessed by single photon emission computed tomography (SPECT) in dogs with congenital portosystemic shunt and hepatic encephalopathy

Matan Or; Kathelijne Peremans; Valentine Martlé; Eva Vandermeulen; Tim Bosmans; Nausikaa Devriendt; Hilde de Rooster

doi:10.1016/j.tvjl.2016.12.009

Regional cerebral blood flow assessed by single photon emission computed tomography (SPECT) in dogs with congenital portosystemic shunt and hepatic encephalopathy

Vet J. 2017 Feb:220:40-42. doi: 10.1016/j.tvjl.2016.12.009. Epub 2016 Dec 21.

Authors

Matan Or¹, Kathelijne Peremans², Valentine Martlé³, Eva Vandermeulen², Tim Bosmans³, Nausikaa Devriendt³, Hilde de Rooster³

Affiliations

¹ Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Electronic address: [email protected].
² Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
³ Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

PMID: 28190492
DOI: 10.1016/j.tvjl.2016.12.009

Abstract

Regional cerebral blood flow (rCBF) in eight dogs with congenital portosystemic shunt (PSS) and hepatic encephalopathy (HE) was compared with rCBF in eight healthy control dogs using single photon emission computed tomography (SPECT) with a ^99mtechnetium-hexamethylpropylene amine oxime (^99mTc-HMPAO) tracer. SPECT scans were abnormal in all PSS dogs. Compared to the control group, rCBF in PSS dogs was significantly decreased in the temporal lobes and increased in the subcortical (thalamic and striatal) area. Brain perfusion imaging alterations observed in the dogs with PSS and HE are similar to those in human patients with HE. These findings suggest that dogs with HE and PSS have altered perfusion of mainly the subcortical and the temporal regions of the brain.

Keywords: (99m)Technetium-hexamethylpropylene amine oxime; Canine; Hepatic encephalopathy; Portosystemic shunt; Single photon emission computed tomography.

MeSH terms

Animals
Brain / blood supply*
Brain / diagnostic imaging
Cerebrovascular Circulation*
Dog Diseases / etiology*
Dogs / abnormalities*
Female
Hepatic Encephalopathy / etiology
Hepatic Encephalopathy / veterinary*
Male
Portal Vein / abnormalities*
Tomography, Emission-Computed, Single-Photon / veterinary
Vascular Malformations

Supplementary concepts

Patent Ductus Venosus