Abstract
Starting from multifunctional triazacyclononane-triphosphinate chelator cores, dendritic molecules with the ability to bind metal ions within their framework were synthesized. A cooperative interaction of the chelator cages resulted in a markedly increased affinity towards 67/68GaIII. A hexameric PSMA inhibitor conjugate with high affinity (IC50 = 1.2 nM) and favorable in vivo PET imaging properties demonstrated practical applicability. The novel scaffolds are useful for synthesis of structurally well-defined multimodal imaging probes or theranostics.
MeSH terms
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Animals
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Aza Compounds / chemistry*
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Chelating Agents / chemical synthesis
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Chelating Agents / chemistry*
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Dendrimers / chemical synthesis
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Dendrimers / chemistry*
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Gallium Radioisotopes / chemistry*
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Humans
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Mice
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Mice, SCID
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Molecular Structure
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Neoplasms, Experimental / diagnostic imaging
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Phosphinic Acids / chemistry*
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Piperidines / chemistry*
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Positron-Emission Tomography
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / chemistry*
Substances
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Aza Compounds
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Chelating Agents
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Dendrimers
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Gallium Radioisotopes
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Phosphinic Acids
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Piperidines
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Radiopharmaceuticals
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triazacyclononane