[Eosinophilic Esophagitis - Update - Pathogenesis, Diagnosis and Therapy]

Laryngorhinootologie. 2017 Jan;96(1):11-21. doi: 10.1055/s-0042-119417. Epub 2017 Feb 13.
[Article in German]

Abstract

Eosinophilic esophagitis (EoE) is a clinicopathological condition of the esophagus that has become increasingly recognised over the last decade. EoE represents a chronic immune-mediated inflammatory disease of the esophagus. In adults dysphagia is the predominant symptom. Upper gastrointestinal endoscopy is required in order to take biopsies from the esophagus. The diagnose is confirmed histologically by typical eosinophilic infiltration of the esophagus mucosa. Until now there is no approved therapy world-wide although we know that topic and systemic steroids are highly effective in EoE. Elimination diet is another option and in well selected patients endoscopic balloon dilation represents a therapeutic possibility.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Animals
  • Biopsy
  • Child
  • Child, Preschool
  • Cytokines / physiology
  • Diagnosis, Differential
  • Disease Models, Animal
  • Eosinophilic Esophagitis / drug therapy
  • Eosinophilic Esophagitis / etiology*
  • Eosinophilic Esophagitis / immunology
  • Eosinophilic Esophagitis / pathology
  • Eosinophils / pathology*
  • Esophageal Mucosa / immunology
  • Esophageal Mucosa / pathology
  • Esophagoscopy
  • Esophagus / immunology*
  • Esophagus / pathology
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / drug therapy
  • Gastroesophageal Reflux / immunology
  • Gastroesophageal Reflux / pathology
  • Humans
  • Infant
  • Leukocyte Count
  • Mice
  • Risk Factors
  • Th2 Cells / immunology
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Cytokines