The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family

J Cell Biol. 2017 Mar 6;216(3):547-549. doi: 10.1083/jcb.201701187. Epub 2017 Feb 13.

Abstract

Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Humans
  • Membrane Proteins / metabolism
  • Mitochondria / metabolism
  • Mitochondrial Membranes / metabolism
  • Peroxisomes / metabolism*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • Voltage-Dependent Anion Channel 2 / metabolism
  • bcl-2 Homologous Antagonist-Killer Protein / metabolism*
  • bcl-2-Associated X Protein / metabolism

Substances

  • Membrane Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Voltage-Dependent Anion Channel 2
  • bcl-2 Homologous Antagonist-Killer Protein
  • bcl-2-Associated X Protein