Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis

Emerg Microbes Infect. 2017 Feb 15;6(2):e8. doi: 10.1038/emi.2017.1.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antitubercular Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial*
  • Heat-Shock Proteins / genetics*
  • Microbial Sensitivity Tests
  • Mutant Proteins / genetics*
  • Mutation, Missense*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / enzymology
  • Mycobacterium tuberculosis / genetics
  • Pyrazinamide / pharmacology*
  • Sequence Analysis, DNA

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • ClpC1 protein, Mycobacterium tuberculosis
  • DNA, Bacterial
  • Heat-Shock Proteins
  • Mutant Proteins
  • Pyrazinamide