Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study

Charles Béguelin; Nicole Friolet; Darius Moradpour; Roland Sahli; Franziska Suter-Riniker; Alexander Lüthi; Matthias Cavassini; Huldrych F Günthard; Manuel Battegay; Enos Bernasconi; Patrick Schmid; Alexandra Calmy; Andrew Atkinson; Andri Rauch; Gilles Wandeler; Swiss HIV Cohort Study

doi:10.1093/cid/cix125

Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study

Clin Infect Dis. 2017 May 1;64(9):1275-1278. doi: 10.1093/cid/cix125.

Authors

Charles Béguelin¹, Nicole Friolet¹, Darius Moradpour², Roland Sahli³, Franziska Suter-Riniker⁴, Alexander Lüthi⁴, Matthias Cavassini⁵, Huldrych F Günthard^{6

7}, Manuel Battegay⁸, Enos Bernasconi⁹, Patrick Schmid¹⁰, Alexandra Calmy¹¹, Andrew Atkinson¹, Andri Rauch¹, Gilles Wandeler^{1

12}; Swiss HIV Cohort Study

Affiliations

¹ Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.
² Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
³ Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
⁴ Institute for Infectious Diseases, Faculty of Medicine, University of Bern, Switzerland.
⁵ Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Switzerland
⁶ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
⁷ Institute of Medical Virology, University of Zurich, Switzerland
⁸ Department of Infectious Diseases & Hospital Hygiene, University Hospital Basel, Switzerland
⁹ Division of Infectious Diseases, Regional Hospital Lugano, Switzerland
¹⁰ Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, Switzerland
¹¹ Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Switzerland.
¹² Institute of Social and Preventive Medicine, University of Bern, Switzerland.

PMID: 28199492
DOI: 10.1093/cid/cix125

Abstract

We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during tenofovir-containing antiretroviral therapy among patients with a replicating HDV infection in the Swiss HIV Cohort Study. Only 28.6% experienced a ≥2.0 log reduction in HDV RNA, and 14.3% had undetectable HDV VL within 5 years.

Keywords: coinfection; hepatitis delta virus; human immunodeficiency virus; replication; tenofovir.

MeSH terms

Adult
Anti-HIV Agents / therapeutic use*
Cohort Studies
Female
HIV Infections / complications*
HIV Infections / drug therapy*
Hepatitis B virus / isolation & purification
Hepatitis B, Chronic / complications
Hepatitis B, Chronic / virology
Hepatitis D / virology*
Hepatitis Delta Virus / drug effects*
Hepatitis Delta Virus / isolation & purification
Hepatitis Delta Virus / physiology
Humans
Male
Middle Aged
Switzerland
Tenofovir / therapeutic use*
Viral Load
Virus Replication / drug effects*

Substances

Anti-HIV Agents
Tenofovir