An unfamiliar or novel physical stimulus induces activation of dopaminergic neurons within the brain and greater activity in areas involved in emotion; considering this, we aimed to establish whether unpredictable prolonged (fatiguing) motor task (vs. constant vs. predictable) evokes greater dopaminergic activity, enhances neuromuscular performance, motor accuracy, and perception of effort, and delays overall central fatigue. Fifteen healthy male volunteers (aged 22 ± 4 years) were required to perform 1 of 3 exercise trials (at least 1 week apart) of 100 intermittent isometric contraction (IIC) tasks involving knee extensions at 60° flexion. Trials were structured differently by simulated contraction intensity. A fatigue task involved 5-s contractions and 20-s rest. Variables measured before, during, and after IIC were electrically induced force, maximal voluntary contraction, central activation ratio, intramuscular temperature, and blood levels of dopamine, cortisol, and prolactin, and intraindividual motor variability and accuracy (constant and absolute error). We found that IIC increased central and peripheral fatigue, force sensation, and T mu, and decreased absolute and constant error without visual feedback, but did not affect motor variability. There were no significant differences between the three IIC tasks. However, only unpredictable tasks increased dopaminergic activity, which was insufficient to affect central motivation to perform isometric exercise and alter centrally mediated components of fatigue.
Keywords: Central and peripheral fatigue; Dopaminergic activity; Motor accuracy; Motor task specificity; Perception.