Abstract
Many studies have noted similarities between atherosclerosis and cancer including pronounced cellular plasticity, clonal expansion of cellular subtypes, increased DNA mutations, defective efferocytosis pathways, and an important role for proto-oncogenes in disease development. Although it is clear that these 2 diseases have disparate causes, noting the parallels between atherosclerosis and cancer may help us identify unique, targeted therapeutic strategies.
Keywords:
atherosclerosis; efferocytosis; macrophages; myocytes, smooth muscle; neoplasms; oncogenes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Atherosclerosis / pathology*
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Causality
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Cell Lineage
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Cell Transformation, Neoplastic / genetics
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Clone Cells / pathology*
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Cyclin-Dependent Kinase Inhibitor p15 / genetics
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Cyclin-Dependent Kinase Inhibitor p15 / physiology
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Genes, Neoplasm
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Genes, Tumor Suppressor
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Humans
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Myocytes, Smooth Muscle / pathology
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Neoplasms / pathology*
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Neoplastic Stem Cells / pathology
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Plaque, Atherosclerotic / pathology
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Risk Factors
Substances
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CDKN2B protein, human
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Cyclin-Dependent Kinase Inhibitor p15